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Urinary Tract Infections


Why d-Mannose May be as Efficient as Antibiotics in the Treatment of Acute Uncomplicated Lower Urinary Tract Infections-Preliminary Considerations and Conclusions from a Non-Interventional Study

Florian Wagenlehner, Horst Lorenz, Oda Ewald and Peter Gerke

Clinic and Polyclinic for Urology, Pediatric Urology and Andrology, Justus-Liebig-University Giessen, 35392 Giessen, Germany; BBS-Büro für Biometrie und Statistik, Im Unterfeld 17, 63543 Neuberg, Germany; MCM Klosterfrau Vertriebsgesellschaft mbH, Gereonsmuehlengasse 1-11, 50670 Cologne, Germany

Keywords

Urinary tract infection, Cystitis, D-mannose, Antibiotics, Acute cystitis symptom score

Abstract

Urinary tract infections (UTIs) are very frequent in women and can be caused by a range of pathogens. High recurrence rates and increasing antibiotic resistance of uropathogens make UTIs a severe public health problem. D-mannose is a monosaccharide that can inhibit bacterial adhesion to the urothelium after oral intake. Several clinical studies have shown the efficacy of D-mannose in the prevention of recurrent UTIs; these also provided limited evidence for the efficacy of D-mannose in acute therapy. A recent prospective, non-interventional study in female patients with acute cystitis reported good success rates for treatment with D-mannose. Here, we present data from a post hoc analysis of this study to compare the cure rate of D-mannose monotherapy with that of antibiotics. The results show that D-mannose is a promising alternative to antibiotics in the treatment of acute uncomplicated UTIs in women.

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